C: Use with warning if Advantages outweigh hazards. Animal scientific tests show possibility and human studies not obtainable or neither animal nor human scientific tests done.

pentobarbital will lower the extent or impact of dapsone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.

pentobarbital will decrease the extent or influence of acalabrutinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

Keep track of Intently (1)pentobarbital will decrease the level or result of tadalafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

pentobarbital will lessen the extent or outcome of fosphenytoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/Observe.

pentobarbital will decrease the extent or outcome of irinotecan liposomal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.

Both increases toxicity of the opposite by pharmacodynamic synergism. Steer clear of or Use Alternate Drug. Profound sedation, respiratory despair, coma, and Loss of life may possibly result if coadministered. Reserve concomitant prescribing of such drugs in individuals for whom other procedure possibilities are insufficient. Limit dosages and durations into the minimum amount essential. Monitor carefully for indications of respiratory depression and sedation.

pentobarbital will increase toxicity of methoxyflurane by rising metabolism. Contraindicated. Enhanced metabolism of methoxyflurane to nephrotoxic compounds.

pentobarbital will click here lessen the level or effect of ritonavir by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

Therapy needs to be administered with warning, if at all, to sufferers who're mentally depressed, have suicidal tendencies, or history of drug abuse

fentanyl transmucosal and pentobarbital both of those improve sedation. Stay away from or Use Alternate Drug. Restrict use to clients for whom choice procedure selections are insufficient

pentobarbital will reduce the level or impact of eucalyptus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.

With therapeutic doses of TCAs, barbiturates enhance metabolism and reduce blood concentrations of TCAs.

pentobarbital will reduce the level or influence of pimavanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Prevent coadministration if at all possible. Keep track of for diminished pimavanserin efficacy. A rise in pimavanserin dosage might be desired.